With so much new information and media attention we will do our best to keep you our customers informed!
Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer's Disease.
Alzheimer's disease (AD) is frequently associated with neuropsychiatric symptoms (NPS) such as agitation and aggression, especially in the moderate to severe stages of the illness. The limited efficacy and high-risk profiles of current pharmacotherapies for the management of agitation and aggression in AD have driven the search for safer pharmacological alternatives. Over the past few years, there has been a growing interest in the therapeutic potential of medications that target the endocannabinoid system (ECS). The behavioral effects of ECS medications, as well as their ability to modulate neuroinflammation and oxidative stress, make targeting this system potentially relevant in AD. This article summarizes the literature to date supporting this rationale and evaluates clinical studies investigating cannabinoids for agitation and aggression in AD. Letters, case studies, and controlled trials from four electronic databases were included. While findings from six studies showed significant benefits from synthetic cannabinoids—dronabinol or nabilone—on agitation and aggression, definitive conclusions were limited by small sample sizes, short trial duration, and lack of placebo control in some of these studies. Given the relevance and findings to date, methodologically rigorous prospective clinical trials are recommended to determine the safety and efficacy of cannabinoids for the treatment of agitation and aggression in dementia and AD. https://www.ncbi.nlm.nih.gov/pubmed/26271310
Cannabidiol (CBD) passes stage 3 clinical trial for the treatment of epilepsy in children.
This one was big. One of the greatest limitations in the medicinal cannabis field is the lack of randomized double-blinded studies, the standard in clinical research. This limitation is often the basis of the opposition’s argument that there’s no strong evidence to support clinical cannabis use. But that argument was undermined by the successful trial of CBD treatment in children with epilepsy... Click link to read more!
Add autism to the list of CBD’s medicinal benefits.
Autism is often the result of too little inhibition in the brain, which leads to heightened sensitivity to stimuli (such as lights, sounds, touch, and smells) and abnormal social behavior. Epilepsy can also result from too little brain inhibition, and it’s common for individuals on the severe end of the autism spectrum to also have epilepsy. Scientists then may study both epilepsy and autism that are caused by the same DNA mutation... Click link to read more!
Addressing 2016’s biggest health scare: Does CBD turn into THC in our stomach?
Source: Journal of Pharmaceutical and Biomedical Analysis, available online December 2017
In 2016, a report claiming that CBD gets converted to THC in the stomach raised fear among proponents and patients. CBD has been emerging as a powerful medicinal tool for treating numerous disorders in children, adolescents, and adults. However, if CBD were to be converted to THC, this could negatively impact brain development in children and adolescents and induce side effects in adults...
Pain and CBD’s Potential Effect
Authors: Karina Genaro, Débora Fabris, Ana L. F. Arantes, Antônio W. Zuardi, José A. S. Crippa, and Wiliam A. Prado; University of São Paulo; National Institute of Science and Technology for Translational Medicine
The phrase “affective-motivational dimension,” refers to the relationship between pain and perception; a rather complex relationship.
Pain is multidimensional; it is “an experience that has somatosensory, affective, motivational and cognitive characteristics.” Pain also affects several regions of the brain, which makes the relationship between pain and perception difficult to analyze.
This study analyzed whether the application of CBD has an effect on pain in the varied ways it can be perceived and experienced. The research yielded several results. Most notable was “systemic” application of CBD reduces mechanical allodynia in the injured subjects.
The researchers concluded that there is evidence “CBD influences different dimensions of the response of rats to a surgical incision.” This is one of the first studies to show that CBD can have an effect on the perception of pain, which paves the way for future research in this area.
A Potential Aid in Brain Recovery After a Stroke
Authors: Ceprián M, Jiménez-Sánchez L, Vargas C, Barata L, Hind W, Martínez-Orgado J; Universidad Complutense de Madrid; Instituto de Investigación Puerta de Hierro Majadahonda, Instituto de Investigación Puerta de Hierro Majadahonda; GW Research Ltd; Instituto de Investigación Puerta de Hierro Majadahonda
Arterial Ischemic Stroke occurs when blood flow in an artery to the brain is blocked due to narrowness of the artery or the formation of a blood clot. Neonatal (i.e. newborn) Arterial Ischemic Stroke grimly means there is a condition specific to infants. Woefully little is known about NAIS, but it can certainly lead to lifelong disabilities and/or brain injury. Currently, there is no effective treatment.
This study demonstrated CBD can reduce brain damage and improve recovery, at least in the neonatal Wistar rat subjects studied. Analyzing the effects to the brain via MRI, behavioral tests, and other system studies, the researchers found that CBD administration after induced artery blockage led to “long-term functional recovery.”
CBD reduced all of the following: the loss of neuronal structure and function, the abnormal increase of astrocytes (a certain type of cell in the brain), cell death and damage, and inflammation of the nervous tissue.
With more clinical studies this treatment could become a reality for human newborns.
Liver Injury and CBD’s Potential Healing Effect
Authors: Yuping Wang, Partha Mukhopadhyay, Zongxian Cao, Hua Wang, Dechun Feng, György Haskó, Raphael Mechoulam, Bin Gao, and Pal Pacher; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Affiliated Hospital of Guiyang Medical University, Rutgers New Jersey Medical School, Hebrew University
This study investigated how CBD could affect subjects with liver injuries resulting from chronic and binge alcohol consumption. CBD was given to subjects (in this case, mice and human blood samples) that had been fed alcohol. In short, the analysis demonstrated that CBD lessened the elevated liver enzymes and the increased liver triglyceride. It also reduced fat droplet accumulation.
Also of note, CBD improved the alcohol-induced liver metabolic impairment and abnormal retention of lipids. Essentially, CBD may be a potential therapeutic treatment for alcoholic liver diseases “associated with inflammation, oxidative stress and steatosis.”
CBD and Irritable Bowel Disease
Authors: Leinwand, Kristina L. DO; Gerich, Mark E. MD; Hoffenberg, Edward J. MD; Collins, Colm B. PhD; National Institutes of Health T32 Institutional Training Grant in Pediatric Gastroenterology; National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health; Colorado Department of Public Health and Environment
Once diagnosed with Inflammatory Bowel Disease (IBD), a person begins a lifelong battle as there is currently no cure. As noted in this review, while modern medicine does tend to allow people to live relatively normal lives, the medicines used to treat IBD can have limited benefits and lose effectiveness.
The review evaluated how targeting the Endocannabinoid System (ECS) could impact colitis. The ECS is a biological system within mammals that is made up of three components: cannabinoid receptors (the things that receive chemical signals outside the cell), endocannabinoids (small molecules that activate cannabinoid receptors), and metabolic enzymes that break down endocannabinoids after they are used.
Results indicated the two main cannabinoid receptors (CB1 and CB2), along with endocannabinoids and atypical cannabinoids are “upregulated in inflammation, and their presence and stimulation attenuate murine colitis.” Put simply: manipulating the ECS can provide substantial relief from colitis.
The review notes that incidents of IBD are on the rise, which reinforces the need for research into new potential therapies. Additionally, IBD results in “an estimated annual disease-attributable direct cost in the United States in excess of $6.3 billion.” That’s 6.3 billion reasons to continue exploring novel therapies.
CBD and Opioid Use: First Long Term Study
Authors: TBD; Albert Einstein College of Medicine and Montefiore Health System
Full disclosure, this is not a published study yet, but the announcement itself is worth including in this list. A 5-year $3.8 million grant was awarded to conduct an 18-month study that will seek to answer whether medical marijuana reduces opioid use among adults with chronic pain.
The study will include adults with HIV as this group, compared with the general public, has higher levels of chronic pain and opioid use.
This is particularly exciting news as it is the first long-term study of this question.
Cannabis vs. Opioid-Based Pain Medication: Patient Self-Report
Authors: Reiman Amanda, Welty Mark, and Solomon Perry; University of California, Berkeley; Kent State University; HelloMD
The goal of this study is to find an alternative to heavy pain medication, which can lead to prescription drug-abuse.
2,897 cannabis-using subjects participated in this survey. Of those who had reported using an opioid medication for pain in the six months prior to the survey, the following responses were gathered after cannabis-use:
- 97% of the sample “strongly agreed/agreed” that they are able to decrease the amount of opiates they consume when they also use cannabis
- 81% “strongly agreed/agreed” that taking cannabis by itself was more effective at treating their condition than taking cannabis with opioids
The participants also reported that cannabis was as effective in providing pain relief as other medications and did not have the “unwanted side effects.” This is incredible given that 63% of participants used cannabis to help manage pain.
While the survey is not specifically about CBD, this is an important area of research into the non-addictive nature of cannabis and lack of side effects that accompany its use. Also, not only is it effective on its own but it can also aid the current use of opioids and decrease the need for such medication.
Ultimately, CBD may one day be a viable replacement for pain-management medications
CBD’s Relevance to Schizophrenia
Authors: Osborne AL, Solowij N, Weston-Green K; Illawarra Health and Medical Research Institute, University of Wollongong
Schizophrenia is a disorder that generally requires heavy antipsychotic drugs just to manage daily life. However, this systematic review notes that such drugs “provide limited cognitive benefits,” which is extremely rough given the side effects antipsychotic drugs can have. As discussed in the review, CBD may be a possible alternative to such heavy prescription drugs.
CBD has both anti-inflammatory and anti-psychotic characteristics. Thus, the aim of the review was to evaluate literature (both preclinical and clinical) on the effects of CBD in relation to schizophrenia. The authors looked through 27 articles from the past 26 years.
The overarching theme of the literature demonstrated that CBD “improves cognition in multiple preclinical models of cognitive impairment,” which includes:
- Alzheimer’s disease
- Neuro-inflammatory conditions (e.g.: Fibromyalgia)
- Neurological disorders (e.g.: Epilepsy)
Due to the lack of clinical evidence, the level and effectiveness that CBD might have cannot be clearly stated. The review is nonetheless an excellent starting point for the future use of CBD in neurological treatments.
CBD Doesn’t Make You Burn Through a Box of Oreos
Authors: Suzanne E.M. de Bruijn, Cees de Graaf, Renger F. Witkamp, and Gerry Jager; Wageningen University
In a test that involved giving volunteers chocolate milk to drink, this study sought the answer to a quirky question: Does CBD (or THC) affect how humans perceive “sweet taste.”
Spoiler: CBD does not.
Over the course of three test sessions the healthy volunteers were randomly given either a placebo, CBD, or THC and then got chocolate-wasted on several samples of chocolate milk, rating the sweetness after each.
The study found that while the THC stimulant did increase a desire to eat, the CBD did not have any effect or intervention on the subjects’ consumption
This also helps support the prior study on this list (“CBD Does Not Get You High”) as it further debunks the notion that CBD has psychoactive effects, e.g. “the munchies.”
Does CBD Get You High?
Authors: Gerhard Nahler, Franjo Grotenhermen, Antonio Waldo Zuardi, and José A.S. Crippa; Department of Neuroscience and Behavior, University of São Paulo Ribeirão Preto, Brazil and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
Delta9-Tetrahydrocannabinol (“THC”) is a hurdle for CBD because THC is the primary psychoactive component in cannabis. This close association between CBD and THC is likely what causes a negative reaction to the thought of using CBD as a medical therapy.
This study combats the notion that CBD causes a THC high by discussing the misinterpretations of prior studies on the subject. In fact, the researchers state that two particular prior studies “have caused much confusion and uncertainty whether oral cannabidiol (CBD) is safe and whether subjects who are treated with CBD run the risk of positive workplace tests [for THC].”
The Prior Studies
The first prior study analyzed the changes in CBD when mixed with a petri-dish simulation of stomach acids. Interpretation of the results yielded the researcher conclusion that CBD does convert to THC when exposed to stomach acids.
The second prior study also suggested CBD may convert to THC when taken orally. The conclusion was based on tests done on human volunteers.
The study authors noted that both prior studies were severely misinterpreted. This is due to two main reasons.
- While CBD might convert to THC under certain simulated acidic conditions, it has not been shown to actually occur in living organisms. This is a classic misinterpretation of what could happen in practicality based solely on culture-dish tests results.
- The results of the human volunteer tests were taken out of context. Traces of THC were not only extremely minimal in the human volunteers but the alleged THC was not present in urine samples.
Author Gerhard Nahler found it most surprising that an entire group of authors were “tempted to over-interpret results.” However, he felt that misinterpretations are not entirely uncommon, stating “People overlook quite frequently that “in vitro” results may differ significantly from conditions “in vivo”, particularly in man. In vitro results are suggestions, not proofs for processes in real life.”
The current study points out that the glaring difference between CBD and THC is the inability for CBD to bind to a person’s cannabinoid brain receptors (more scientifically referred to as “CB1”). As CBD does not initiate a physiological response when combined with CB1, it “lacks cannabis-like intoxicating effects.”
The researchers note that while conversion to THC may occur under artificial conditions “Over 40 years of research on CBD does not suggest a conversion of CBD to delta9-THC and/or other cannabinoids in vivo after oral administration.”
To avoid misinterpretations in the future, Nahler noted “The more a result is unexpected (or presented as such as it was in the paper of Merrick et al., 2016) the more authors should be cautious when interpreting and extrapolating results.”
This is a truly impactful study for CBD use as it takes direct aim at the common-yet-faulty belief that CBD is a psychoactive compound.
Does CBD Reduce High Blood Pressure?
Authors: Khalid A. Jadoon, Garry D. Tan, and Saoirse E. O’Sullivan
High blood pressure is a globally ubiquitous issue. This study explores the connection between CBD and a reduction in blood pressure. It is particularly unique as it is noted that “there are no dedicated studies in humans to date, to our knowledge, looking at the effect of CBD on either resting cardiovascular measurement or on the responses to stress, with continuous monitoring of CV parameters.”
In a randomized, placebo-controlled, double-blind, crossover study, nine healthy male volunteers were given either 600 mg of CBD or a placebo. They were then monitored for changes in their cardiovascular system.
Using stress tests, such as math without a calculator, cardiovascular outputs were monitored. The study found that CBD reduced resting systolic blood pressure and stroke volume. It also “blunted the blood pressure response to stress[….]”
High blood pressure has a multitude of potential treatments, including diet and exercise. This study essentially adds CBD to the list. The data from this research is also important as information for potential side-effects of CBD.
Potential Anti-panic Actions of CBD
Authors: Vanessa P. Soares and Alline C. Campos
This review opens strong, stating: “Panic disorder (PD) is a disabling psychiatry[sic] condition that affects approximately 5% of the worldwide population.” The percentage itself might sound small, but it is actually 355 million people. This is a staggering number of people who suffer from anxiety.
The authors analyzed prior human and animal studies to consolidate the information and make an overarching determination as to the therapeutic effect of cannabinoids, particularly, CBD. The article looked to a multitude of findings from prior studies such as human anxiety in public speaking and electrical stimulation in animal subjects.
Long story short, this article confirmed that CBD appears to be a promising treatment for panic disorders.
The most compelling conclusion is CBD is not habit-forming and doesn’t decrease tolerance. Thus, it could be a solid alternative for “high potency benzodiazepines and antidepressant drugs in PD patients who are resistant to the current treatments.”
This is incredibly encouraging not only for those with panic disorder but also those with varying types of anxiety who currently rely on psychiatric medications.
Afraid of Public-Speaking? CBD Might Help
Authors: Antonio W. Zuardi,Natália P. Rodrigues, Angélica L. Silva, Sandra A. Bernardo, Jaime E. C. Hallak, Francisco S. Guimarães, and José A. S. Crippa; University of São Paulo, National Institute of Science and Technology for Translational Medicine, National Council for Scientific and Technological Development
Fear of public speaking, also known as Glossophobia, is incredibly common and most people have experienced it at some point in their lives. This double-blind study involved a total of 60 males and females between the ages of 18 and 35.
The subjects were divided into 5 groups who randomly received either a placebo, CBD in 100mg, 300mg or 900mg, or clonazepam (a medication used to treat panic disorders) following the experimental procedure in the graphic below:
Each participant gave a speech in front of the other participants, after which he or she again filled out the questionnaire on anxiety level (see graphic) and again had his or her blood pressure and heart rate taken.
Clonazepam was the obvious front runner, consistently reducing anxiety in a more sedative way than the placebos and CBD administration. However, CBD at a dosage of 300mg was shown to significantly reduce subjective anxiety in the post-speech phase. The same was not true for the 100mg and 900mg dosage.
This study’s true focus was the varied dosage; seeking whether administration of CBD produces an “inverted U-Shaped dose response.”
We spoke with Antonio Zuardi, who told us this phrase “refers to a concept that a given drug is effective with an intermediate dose, but not with smaller or larger doses.” CBD did indeed produce such a response.
As such, Zuardi noted that “These findings stress the importance of the careful choice of dose ranges when investigating the potential therapeutic effects of CBD.”
The dosing is obviously vital but the real-life impact of this study is that CBD could be used to manage anxiety.
Can CBD Help Manage Fear?
Authors: Stern CAJ, da Silva TR, Raymundi AM, de Souza CP, Hiroaki-Sato VA, Kato L, Guimarães FS, Andreatini R, Takahashi RN, Bertoglio LJ; University of Parana, University of São Paulo, Federal University of Santa Catarina
Fear is something everyone can relate to. In fact, over 25 million people in the U.S. will experience PTSD at some point in their lives. This study looked at how CBD might weaken fear-response related to an adverse memory (like PTSD).
The results of this study, while based on fear in a more esoteric sense, do appear to suggest that CBD may one day play a vital role in the management of such a prevalent disorder.
The furry subjects, 277 Wistar rats, were given a dose of CBD immediately after receiving a small electric shock. The CBD-treated subjects were found to spend less time frozen in fear when reintroduced to the context of the fearful event. This means the CBD disrupted consolidation (or more simply put: memory strengthening) of their specific and long-term fear memory.
CBD was also found to disrupt the consolidation of generalized fear memories when administered immediately after the acquisition of such fear memory. Interestingly, the timing of the administration of CBD was vital as the results demonstrated that delayed administration of the CBD dose did not have the same effective result that immediate administration did.
The findings of this study could have a huge impact on PTSD management.
Seizures in Children and How CBD Therapy Might Help
Authors: Orrin Devinsky, M.D., J. Helen Cross, Ph.D., F.R.C.P.C.H., Linda Laux, M.D., Eric Marsh, M.D., Ian Miller, M.D., Rima Nabbout, M.D., Ingrid E. Scheffer, M.B., B.S., Ph.D., Elizabeth A. Thiele, M.D., Ph.D., and Stephen Wright, M.D.; Cannabidiol in Dravet Syndrome Study Group
Similar to the study above, this studyexplores the effects of CBD therapy in relation to seizures, but is focused on children with Dravet Syndrome.
Dravet Syndrome is a rare genetic epileptic neurological disorder that develops in the first year of a child’s life. It can cause developmental disabilities and is currently treated by finding the best mix of medications to manage the child’s seizures.
Unfortunately, traditional medications and treatments generally seek only to minimize the symptoms which is, unfortunately, typically a lost cause as the seizures from this condition are refractory.
Trial Parameters and Process
The parameters of this trial are particularly impressive and add to the integrity of the results:
- Subject pool of 120 children and young adults with Dravet syndrome and drug-resistant seizures
Over the course of a 14-week treatment period, the subjects were randomly assigned either a daily dose of CBD oral solution based on body weight or a placebo. The doses were given in conjunction with each subject’s standard antiepileptic treatment.
While the rate of non-convulsive seizures did not change, the CBD-treated convulsive seizures decreased from 12.4 to 5.9 percentage points – almost half. The placebo group only decreased by 0.8. In addition, 5% of patients who were given CBD became seizure free, compared with none in the placebo group.
It’s important to note that the CBD group did experience more severe side-effects, including vomiting and fever. However, these side-effects should be put in context. An astonishing 62% of the CBD group reported an significant increase in their overall condition, compared with on 34% of the placebo group.
The results are certainly compelling. However, the adverse side-effects warrant a more comprehensive, long-term study to investigate the continued use of CBD for Dravet Syndrome sufferers.
CBD and Treatment-Resistant Seizures
Authors: G. Pesántez-Ríos, L. Armijos-Acurio, R. Jimbo-Sotomayor, S.I. Pascual-Pascual, G. Pesántez-Cuesta
An Explanation of Epilepsy
Having a medical condition is difficult enough, but if that condition doesn’t respond to medical treatment, life can become a constant battle. Refractory epilepsy is also known as uncontrolled or drug-resistant epilepsy. This means that a person who is suffering from refractory epilepsies is not responding to traditional medicine and thus is unable to effectively manage his or her neurological disorder.
As of 2014, 50 million people worldwide suffer from epilepsy (more than Parkinson’s disease and cerebral palsy combined), and it is the fourth most common neurological disorder in the United States. Of that 50 million, approximately 1/3 – over 16 million – are unresponsive to antiepileptic medication and other medical treatments.
Study Parameters and Results
A group of 15 patients who received CBD over a period ranging from one month to one year were surveyed to gather various data. The researchers sought information about the patient and the caregiver, changes observed in the seizures, neuropsychological effects, side effects and the family’s overall perception following the use of cannabidiol. This simple observational study identified some very encouraging findings:
- Frequency of seizures: Decreased in 40% of patients, disappeared completely in 27% of patients.
- Level of patient-control over seizures: 60% of patients were able to control 50% of their seizures.
- Neurocognitive changes: Many patients experienced improvements in behavior, language, sleep, and eating habits. Moreover, 100% of the patients reported that their mood had improved after the use of CBD.
- Side effects: Most common were drowsiness and fatigue.
The impact of this study could be far-reaching both for patients with refractory epilepsy as well as patients with epilepsy who feel compelled to try other treatment methods.
CBD Research Round-Up
Authors: Kerstin Iffland and Franjo Grotenhermen; nova-Institut, Hürth, Germany
A logical start to this list is an overall update on CBD. Published in June, this review evaluated a massive amount of existing research, data, and studies with the intent to update and synthesize vast amounts of data.
- CBD is safe to use
- There is a major need for more research as the majority of studies were performed for treatment of epilepsy and psychotic disorders
- Most common side effects reported are tiredness, diarrhea, and changes of appetite/weight.
- CBD has comparatively fewer side-effects compared with prescription medication
- The fewer side-effects could help increase patient-adherence to treatment
- CBD can be used as a supplemental therapy
To put the CBD side-effects in perspective, other drugs used for the same medical condition have far more negative side-effect profiles. This is particularly important as choosing a treatment with fewer side-effects could help ensure patients actually follow their treatment plans.
As to the safety of CBD use, the authors stated that the “safety profile is already established in a plethora of ways” and the breadth of their review serves to substantiate and build upon this notion.